Published 16 May 2022 The goal is to examine the risk of conception mode-type-1 diabetes using different survival analysis modelling approaches and examine if there are differentials in the risk of type-1 diabetes between children from fresh and frozen-thawed embryo transfers. We aimed to compare the performances and fitness of different survival analysis regression models with the Cox proportiona

https://www.lupop.lu.se/article/comparison-performances-survival-analysis-regression-models-analysis-conception-modes-and-risk-type - 2025-05-25

Published 21 April 2017 Six researchers from Lund University Diabetes Centre have recieved prestigous grants from the European Research Council (ERC). In order to celebrate the success we invited the public to an open seminar. Some of the talks can be reviewed here (in Swedish). Forskning för bättre folkhälsa:Framsteg inom typ 2-diabetes, fetma och hjärtsjukdomar   Föredrag av professor Olle Melan

https://www.ludc.lu.se/article/successful-research-funded-european-research-council - 2025-05-25

Published 24 May 2017 They govern everything we think and do, they give us the ability to feel pain and to secrete insulin: they are the ion channels that are present in every one of our cells and that control the electrical impulses in our nerve and muscle cells. “For me, they are the very spark of life”, says Dame Frances Ashcroft, professor at the University of Oxford, who is also now to be an

https://www.ludc.lu.se/article/injections-pills-research-neonatal-diabetes - 2025-05-25

Published 29 May 2017 Four researchers have been awarded grants from The Bo and Kerstin Hjelt Diabetes Foundation. The grant consists of Euro 50 000 each and are aiming towards better treatments and prevention of type 2-diabetes. Improved life expectancy and quality of people with diabetesDiabetes affects millions of patients around the world. The two main types of the disease, type 1 and type 2,

https://www.ludc.lu.se/article/200000-euro-diabetes-research - 2025-05-25

Published 15 June 2017 There has been no known link between diabetes and vitamin A -- until now. A new study suggests that the vitamin improves the insulin producing β-cell´s function.The researchers initially discovered that insulin-producing beta-cells contain a large quantity of a cell surface receptor for vitamin A. "There are no unnecessary surface receptors in human cells. They all serve a p

https://www.ludc.lu.se/article/role-vitamin-diabetes - 2025-05-25

Published 3 July 2017 Research from King’s College in London, UK, and Lund University in Sweden could explain why diabetes drugs which have worked in animal experiments are not equally successful in humans. The researchers discovered differences – but also unknown similarities – in the function of insulin-producing beta cells. The team have mapped a category of receptors, known as G protein-couple

https://www.ludc.lu.se/article/new-research-describes-differences-between-mice-and-humans - 2025-05-25

By sara [dot] liedholm [at] med [dot] lu [dot] se (Sara Liedholm) - published 14 September 2017 Taking advantage of a novel sub-classification of diabetes LUDC-IRC, a newly launched collaboration between academia, the health care system and industry, aims at delivering precision medicine in diabetes. LUDC-IRC consolidation meeting  - We have set the bar high. We very specifically aim at making a d

https://www.ludc.lu.se/article/ludc-irc-ready-take - 2025-05-25

Published 17 November 2017 Can insulin taken as an infant in small doses together with food render the immune system used to insulin and thus prevent type 1 diabetes? Can a gluten-free diet and probiotics prevent celiac disease (so called gluten intolerance)? These questions will be asked by two separate studies that are being planned at Lund University in Sweden. A new comprehensive screening of

https://www.ludc.lu.se/article/newborn-babies-be-screened-studies-type-1-diabetes-and-celiac-disease-gluten-intolerance - 2025-05-25

Published 17 November 2017 Food researchers at Lund University in Sweden have discovered that consuming small amounts of chromium mixed with certain amino acids before eating is healthy. Why? Well, this mixture diluted in water suppresses the blood sugar spike that occurs when we eat. Now, they are hoping that the drink – which tastes like ordinary mineral water – will be able to compete with soft

https://www.ludc.lu.se/article/new-drink-keeps-blood-sugar-check - 2025-05-25

Published 17 November 2017 There has been a fear that the swine flu vaccine, Pandemrix, would increase the risk of autoimmune diseases other than narcolepsy. However, a new study of children from Sweden and Finland shows that the vaccine increased neither the risk of developing autoantibodies against insulin-producing beta cells nor the occurrence of type 1 diabetes. Helena Elding Larsson “On the

https://www.ludc.lu.se/article/risk-type-1-diabetes-not-increased-swine-flu-vaccine-pandemrix - 2025-05-25

Published 14 December 2017 Researchers at Lund University in Sweden have found that the presence of death receptors in the blood can be used to directly measure the risk of developing cardiovascular diseases and type 2 diabetes. “We see that people with known risk factors such as high blood sugar and high blood fats also have heightened death receptor levels”, says Professor Jan Nilsson who led th

https://www.ludc.lu.se/article/death-receptors-new-markers-type-2-diabetes-and-cardiovascular-disease - 2025-05-25

Published 14 December 2017 December 4-5, nordic researchers gathered in Malmö to discuss future challenges in precision medicine, a research field where diagnosis and treatment are based on the individual´s genetic and biological conditions. Focus is on our common and increasing diseases diabetes, cardiovascular disease, cancer and psychiatric diagnosis. "The goal of the meeting is to bring togeth

https://www.ludc.lu.se/article/nordic-conference-malmo-about-precision-medicine-future - 2025-05-25

Published 2 March 2018 A completely new classification of diabetes which also predicts the risk of serious complications and provides treatment suggestions. We are now seeing the first results of ANDIS – a study covering all newly diagnosed diabetics in southern Sweden — published in The Lancet Diabetes & Endocrinology. The major difference from today’s classification is that type 2 diabetes actua

https://www.ludc.lu.se/article/paradigm-shift-diagnosis-diabetes - 2025-05-25

By anna [dot] axmon [at] med [dot] lu [dot] se (Anna Axmon) - published 8 June 2021 This study extends TCAL by disentangling causes of death contributions. The strength of the approach is that it allows identification of mortality differences in cohorts with members still alive, as well as identification of which ages and causes of death contribute to mortality differentials between populations. R

https://www.lupop.lu.se/article/reflection-modern-methods-cause-death-decomposition-cohort-survival-comparisons - 2025-05-25

By anna [dot] axmon [at] med [dot] lu [dot] se (Anna Axmon) - published 9 June 2021 Advances in synthetic control methods bring new opportunities to conduct rigorous research in evaluating public health interventions. However, incorporating synthetic controls in interrupted time series studies may not always nullify important threats to validity nor improve causal inference. Read the paper at http

https://www.lupop.lu.se/article/can-synthetic-controls-improve-causal-inference-interrupted-time-series-evaluations-public-health - 2025-05-25

By anna [dot] axmon [at] med [dot] lu [dot] se (Anna Axmon) - published 10 June 2021 Concerns have been expressed over standards of statistical interpretation. Results with P <0.05 are often referred to as ‘significant’ which, in plain English, implies important. This leads some people directly into the misconception that this provides proof that associations are clinically relevant. Read the pape

https://www.lupop.lu.se/article/reflection-modern-methods-statistics-education-beyond-significance-novel-plain-english - 2025-05-25

By anna [dot] axmon [at] med [dot] lu [dot] se (Anna Axmon) - published 17 June 2021 Standard errors are usually calculated based on assumptions underpinning the statistical model used in the estimation. However, there are situations in which some assumptions of the statistical model including the variance or covariance of the outcome across observations are violated, which leads to biased standar

https://www.lupop.lu.se/article/reflection-modern-methods-demystifying-robust-standard-errors-epidemiologists - 2025-05-25

By anna [dot] axmon [at] med [dot] lu [dot] se (Anna Axmon) - published 15 June 2021 The IDAG allows for a both intuitive and stringent way of illustrating interactions. It helps to distinguish between causal and non-causal mechanisms behind effect variation. Read the paper at https://academic.oup.com/ije/article/50/2/613/5998421

https://www.lupop.lu.se/article/directed-acyclic-graph-interactions - 2025-05-25

By anna [dot] axmon [at] med [dot] lu [dot] se (Anna Axmon) - published 11 June 2021 Photo: Pixabay / Gerd Altmann Directed acyclic graphs (DAGs) are an increasingly popular approach for identifying confounding variables that require conditioning when estimating causal effects. This review examined the use of DAGs in applied health research to inform recommendations for improving their transparenc

https://www.lupop.lu.se/article/use-directed-acyclic-graphs-dags-identify-confounders-applied-health-research-review-and - 2025-05-25

By anna [dot] axmon [at] med [dot] lu [dot] se (Anna Axmon) - published 12 June 2021 Statistical learning methods beyond generalized linear models, such as shrinkage methods or kernel smoothing methods, are being increasingly implemented in public health research and epidemiology because they can perform better in instances with complex or high-dimensional data—settings in which traditional statis

https://www.lupop.lu.se/article/reflection-modern-methods-good-practices-applied-statistical-learning-epidemiology - 2025-05-25